glp-1 and cardiovascular benefits Complementary Yet Distinct Roles of Receptor Agonists SGLT2 Inhibitors in Risk Reduction glp 1 effect on heart

As summarized in Table S1, the level of evidence is still low, derived mainly from in vitro studies, animal models, and small patient cohorts, with only limited data from RCT available

If you want a broader overview of this treatment class, our guide to GLP-1 therapy and how it supports weight loss is a helpful place to start

[2] NICE does recommend liraglutide (Saxenda) as an option for managing overweight/obesity in adults in Tier-3 services and with specific BMI criteria (TA664)

For weight management, GLP-1 medicines can help people feel fuller, reduce appetite and support weight loss when used alongside diet, physical activity and ongoing clinical support

In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin