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Safety and efficacy of glucagon-like peptide-1 receptor agonists in children and adolescents with obesity: A meta-analysis
In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)
Assessment of risk of bias in included studies The quality of the studies included in this review was assessed by two independent reviewers using the Cochrane risk of bias tool 2 (RoB 2) [32]
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