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Why this trial matters: Provides real-world evidence on first-line regimens in a poor-prognosis mCRC subtype Highlights superior survival with chemo + anti-VEGF versus chemo alone or targeted therapy Reinforces the importance of personalized treatment strategies and further trials Eli Lilly Retatrutide Delivers Unprecedented Weight Loss in Phase III TRIUMPH-4 Trial Eli Lillys investigational triple-agonist retatrutide produced an average ~28.7% body-weight reduction (71.2 lbs) at 68 weeks in the Phase III TRIUMPH-4 obesity trial, along with meaningful knee osteoarthritis pain relief, marking one of the strongest weight-loss results reported in late-stage obesity research

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doi: 10.1016/0014-5793(96)01027-7

Individual patient factors The safety and tolerability of this combination may vary depending on a patient's age, comorbidities, and other medications

Funding Both studies were funded by Novo Nordisk A/S and are registered with ClinicalTrials.gov (NCT04209049 and NCT05564104)