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Acamprosate (Campral) Acamprosate works through a different mechanism than naltrexone, modulating the glutamate system to reduce the neurological hyperexcitability that produces post-acute withdrawal symptoms including anxiety, restlessness, and alcohol cravings in people who have achieved abstinence

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And of course we have a number of patients with chronic kidney disease who, as you mentioned, pass away presumably prematurely in the absence of the availability of these drugs from cardiovascular causes