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Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it

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To keep their complicated three-dimensional structures that affect how they connect to receptors, both compounds need to be handled with care

a further period of recycling with agonist washed off and replaced with 10 M exendin(9-39)