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The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants legal guardians/next of kin because Written informed consent was waived by the ethics committee because this retrospective study used anonymized clinical data, and an opt-out method was employed in accordance with the guidelines of the institution

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The Phase 2 trial of retatrutide (Jastreboff et al., New England Journal of Medicine , 2023) reported that the most common adverse effects were gastrointestinal in nature (nausea, vomiting, diarrhoea), consistent with the GLP-1 receptor agonist class

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