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Structural basis of detection and signaling of DNA single-strand breaks by human PARP-1

PMID 8277174

For example, recent studies have shown that perturbation of COQ2, a key enzyme responsible for coupling the isoprenoid tail to the quinone head group, increases ferroptosis sensitivity, and thus targeting COQ2 enhances ferroptotic vulnerability in multiple myeloma cells 35

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The laser beam is then deflected by the epi-illumination system (dichroic mirror or semireflecting glass) and focused on the sample through the microscope objective (X63 Zeiss Neofluar water-immersion objective