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Statements Author contributions QZ conceptualized the manuscript

While the total volume may differ (e.g., 1mL, 0.5mL, 0.3mL), all U-100 insulin syringes are calibrated the same: 100 units equal 1 mL

Quantification of mitochondrial superoxide was similarly executed except that the samples were stained with 5 M MitoSox TM Red (Thermo Fisher Scientific)