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Concretely, lactylation of NEDD4, a negative regulator of Caspase-11, impedes Caspase-11 ubiquitination by decreasing its interaction with Caspase-11, thereby triggering pyroptosis in macrophages and exacerbating acetaminophen-induced liver injury (AILI)

Its primary clinical discussion centers on its role in telomere biology, where research suggests it may influence telomerase activity, the enzyme responsible for maintaining telomere length

Tang, S., Guo, W., Kang, L

Further analysis revealed that the T162A mutation alone was sufficient to inhibit SAPK2 phosphorylation, whereas the T159A mutation had no such effect (Fig

SAR405 is an inhibitor of autophagy initiation, which interferes with autophagosome formation at the nucleation step, potently inhibiting VPS34 (Ohashi, 2021)