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However, additional pharmacological studies are needed to improve the treatment efficacy in terms of dose, route of administration or combination of administered drugs

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On the other hand, the gdh3 / gdh3 mutant showed similar growth kinetics to the wild-type cells when grown on arginine as the sole carbon and nitrogen source, but the gdh2 / gdh2 strain showed minimal growth (0.009 h 1 ) and biomass yield (0.016 g L 1 ) compared to the wild-type strain (growth rate = 0.068 h 1 , biomass = 0.50 g L 1 )

There are three main types of medical therapy, including somatostatin receptor ligands (SRL), GHR antagonists and dopamine agonizts 42,43 (Table 1)