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Drucker, MD, a professor of medicine at the Lunenfeld Tanenbaum Research Institute of Mount Sinai Hospital and the University of Toronto, knee osteoarthritis, often exacerbated by concomitant obesity, may be more amenable to improvement via weight loss

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This means retatrutide activates the GIP receptor most aggressively, the GLP-1 receptor at moderate strength, and the glucagon receptor at the lowest level

By influencing hormones such as GLP-1, GIP, and glucagon, retatrutide not only curbs hunger but also enhances insulin sensitivity, making it a promising option for individuals struggling with obesity and type 2 diabetes