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In the same AIA rabbit model, it was found that the parathyroid hormone related protein (PTHrP) was detected in diseased cartilage chondrocytes, suggesting that it has a role in this pathological condition, with a decrease in cell and matrix PTHrP in late AIA in parallel with the loss of chondrocytes, as happens in human RA cartilage (106)

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GLP-1 agonists, such as liraglutide and semaglutide, are increasingly used in medical weight loss due to their ability to mimic the natural hormone glucagon-like peptide-1, which is, for the most part, responsible for regulating appetite and food intake

Chen C, Li Q, Nie X, Han B, Chen Y, Xia F, Zhai H, Wang N, Lu Y (2017) Association of lead exposure with cardiovascular risk factors and diseases in Chinese adults