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Additionally, PXR activation leads to the upregulation of SREBP2 and HMGCR and broadly induces cholesterol synthesis both in mice experiments and clinical researches (85)

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PLoS One 10, e0134676

A double-blind, randomized controlled trial using 2% topical oxidized glutathione (GSSG) demonstrated significant skin-lightening effects after 10 weeks ( Watanabe et al., Clinical, Cosmetic and Investigational Dermatology, 2014 )