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To view or add a comment, sign in More Relevant Posts Phase 3 TRANSCEND: Setmelanotide achieved a 16.5% reduction in BMI over 52 weeks by directly activating MC4R and bypassing impaired leptinPOMC signalingmarking a significant advance for patients with acquired hypothalamic obesity

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Work with your healthcare provider to establish baseline vital signs, review ECG results if indicated, and schedule regular monitoring during titration

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