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Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alstrom syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period

Redness, swelling, or itching at the injection site Tip: Let the alcohol swab air-dry, rotate sites faithfully, and apply a cool compress for a few minutes afterward

First, we used CMS4-derived organoids (from a patient with PM) in which the catalytic subunit of glutamate-cysteine ligase (GCLC) was deleted using CRISPR-CAS9 technology

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Crosstalk between glutamine metabolism and oncogenic signaling The excessive proliferation exhibited by cancer cells demands a constant supply of fuels such as glucose and glutamine