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The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others

This includes prior authorization and quantity limits put in place to ensure that members are using the right medications for their condition, as well as the right amount of medication

GoodRx offers the Wegovy pill as well as injectable Wegovy, Ozempic, Mounjaro, Zepbound, and Saxenda

Patients with depression, anxiety disorders, or insomnia should be evaluated carefully before adding phentermine

GLP-1 receptor agonist drugs (e.g., semaglutide, liraglutide, tirzapeptide) work by mimicking natural GLP-1 but last much longer