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As explained by Stanford, People might begin with oral medications to achieve initial weight loss or glycemic control, and then transition to injections if more intensive treatment is needed. On the flip side, a step-down approach can be used to simplify things or lower treatment intensity after reaching goals

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(3) Following exposure, the sarinAChE complex undergoes aging, a dealkylation process that stabilizes the enzyme-inhibitor bond and reduces oxime-mediated reactivation

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