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In diabetic mice, podocyte-specific overexpression of JAK2 exacerbates pathological changes, including urinary albumin excretion, mesangial expansion, glomerular basement membrane thickening, and renal tubular interstitial fibrosis [246]

Natural killer T cells The innate immune system activates NKT cells promptly during the immune response because of their capacity to deliver direct cytotoxic effects and swiftly generate cytokines

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Within the tumor microenvironment, this cross-talk is further complicated by the coexistence of tumor and immune cells, both of which undergo metabolic reprogramming