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Seungpyo Hong and Ryan Pearson for helpful discussions of experiments for this manuscript

This process is particularly pronounced when glutathione (GSH) is depleted or glutathione peroxidase 4 (GPX4), a key enzyme that prevents lipid oxidation, is inhibited [39]

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Weight regain typically begins within 4-6 weeks after stopping, with research showing that 50-80% of lost weight returns if no lifestyle interventions replace the medication's effects