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Metformin treatment should not be initiated in patients 80 years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced, as these patients are more susceptible to developing lactic acidosis

This parallels the Tier-N supplier risk disclosure recommended for biologics but applies to the R&D layer rather than the commercial manufacturing layer

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Green Tea extract is valued for its naturally occurring bioactive compounds and is commonly used to support metabolism and overall wellness